Track1099 has been the best software I've used to process 1099s. It is very easy to use, allowing you to either enter vendors manually or upload a vendor list. From year to year, it pre-populates with the vendors from the prior year so you don't have to re-enter them; just edit, add and delete as needed. It gives the ability to either email or mail 1099s to recipients, files electronically with the IRS, and tracks the 1099 filing throughout the process. The fees are also very reasonable. I am very happy with the software.